Cristino Lab

Decoding the genomic architecture of brain disorders

The Cristino Lab integrates neurogenomics, regulatory biology, and systems-level modelling to uncover the molecular mechanisms underlying complex neuropsychiatric and medical conditions.

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About the lab

From genome to phenome: brain disorders as dysfunctional gene networks

The Neurogenomics and Systems Biology Laboratory is focused on understanding how genetic variation and regulatory non-coding elements contribute to complex neuropsychiatric and medical conditions. Our research spans schizophrenia, Alzheimer's disease, rare genetic disorders, and cancer immunotherapy.

We develop computational pipelines to interrogate large-scale genomic and transcriptomic datasets — integrating multi-omics, regulatory element annotation, and small RNA biology to build mechanistic models of gene dysregulation in disease.

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Institutional Affiliation

We are part of the Institute for Biomedicine and Glycomics (IBG) at Griffith University, Brisbane, Australia — an internationally recognised research centre advancing biomedical science and translational medicine.


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Research

Two pillars: Basic and Medical research

Basic Research

Regulatory Non-Coding RNAs & Gene Networks

Characterising miRNA, circRNA, and lncRNA regulatory networks. Building protein–protein interaction networks and multi-omics integration pipelines to model gene dysregulation.

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Medical Research

Schizophrenia, Alzheimer's & Cancer

Translational research programs spanning schizophrenia genomics, Alzheimer's disease biomarkers, rare genetic diseases, and cancer immunotherapy mechanisms.

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Publications

49 Publications · 6,200+ Citations

From landmark genome consortia to cutting-edge miRNA studies. Full publication list with research syntheses available for each paper.

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Collaborations

National & International Partners

We work with leading research groups across Australia and internationally, spanning genomics, clinical neuroscience, stem cell biology, and immunotherapy.

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