About

Neurogenomics & Systems Biology Laboratory

Understanding how genetic variation, regulatory non-coding elements, and gene networks contribute to complex neuropsychiatric and medical conditions — from molecular mechanisms to translational insights.

Principal Investigator

Dr. Alexandre S. Cristino

Dr. Alexandre S. Cristino

Alexandre S. Cristino, PhD

Group Leader — Neurogenomics and Systems Biology Laboratory
Institute for Biomedicine and Glycomics (IBG) · Griffith University · Brisbane, Australia

Dr Alexandre Cristino is a mid-career molecular biologist (MSc in Genetics, 2002, University of São Paulo, Brazil) and bioinformatician (PhD in Bioinformatics, 2007, University of São Paulo, Brazil) with an extensive track record in multidisciplinary research spanning bioinformatics, systems biology, molecular biology, neurological disorders, and cancer.

He has published 49 peer-reviewed articles with an h-index of 30 and more than 6,200 citations (Google Scholar). Dr Cristino has made major contributions to high-impact studies published in leading journals including Nature, Science, Molecular Psychiatry (one first/corresponding author and two senior author papers), Blood (first/corresponding author), Nature Communications (one first author and one co-author paper), and Clinical and Translational Medicine (senior author).

In 2015, Dr Cristino established an independent research program in functional neurogenomics and systems biology as a group leader at the University of Queensland Diamantina Institute (now Fraser Institute, Translational Research Institute). In January 2019, he was recruited to Griffith University as a strategic appointment to lead a multidisciplinary research program at the Griffith Institute for Drug Discovery (now the Institute for Biomedicine and Glycomics).

His excellence in research training and mentoring is demonstrated by 20 completed higher degree research supervisions (6 PhDs, 6 MSc, and 8 Honours). Dr Cristino has secured over $9M in competitive funding, including an NHMRC 2023 Ideas Grant, an MRFF 2022 Stem Cell Therapies Mission Grant, an MRFF 2021 Rare Cancers, Rare Diseases and Unmet Need Grant, an ARC Discovery Project, multiple internal and philanthropic grants (>$1.6M), and five PhD scholarships as principal supervisor.

49
Publications
6,200+
Citations
30
h-index
AU$9M+
Competitive funding
Research Areas

Neurogenomics · Systems Biology · Regulatory non-coding RNAs (miRNA, circRNA) · Gene network analysis · Multi-omics · Schizophrenia · Alzheimer's disease · Rare genetic diseases · Cancer immunotherapy


Current Affiliation

Institute for Biomedicine and Glycomics (IBG)
Griffith University, Nathan Campus
Brisbane QLD 4111, Australia


ORCID

0000-0002-3468-0919

Laboratory Overview

Bridging computation and experiment

The Neurogenomics and Systems Biology Laboratory develops computational pipelines and algorithms to interrogate large-scale genomic and transcriptomic datasets — integrating GWAS findings, eQTL analyses, regulatory element annotation, and small RNA biology to build mechanistic models of gene dysregulation in disease.

Our work bridges wet-lab molecular biology and high-performance computation. On the experimental side, we use patient-derived stem cells (olfactory neurosphere-derived cells, iPSCs) and primary cell cultures as disease-relevant models. On the computational side, we develop and apply algorithms for miRNA target prediction, circRNA identification, gene network analysis, and multi-omics data integration.

The lab is embedded within the Institute for Biomedicine and Glycomics (IBG) at Griffith University, providing access to state-of-the-art facilities for automated imaging, high-throughput screening, and translational research.

Funding

Grants & competitive funding

2024 – 2027
NHMRC Ideas Grant

PILRB, a potential mediator of microglia phagocytic failure in Alzheimer's disease

CIA: Quek · CIB: White · CIC: Cristino · Grant #2029183
AU$ 814,000
2022 – 2027
NHMRC MRFF — Clinical Trials Activity, Rare Cancers & Rare Diseases

An early phase, open label, multi-centre trial of front-line TheRapy for EBv-associated Lymphomas – 2: TREBL-2

CIA: Gandhi · CIH: Cristino · Grant #2021 MRFF
AU$ 2,800,000
2022 – 2025
NHMRC Medical Research Future Fund (MRFF) — Stem Cell Therapies Mission

Drug discovery for schizophrenia using patient-derived stem cells

CIA: Cristino · CIB: Avery · CIC: Mackay-Sim · CID: Berk · CIE: Walder · Grant #2017861
AU$ 1,400,000
2022
Genetic Cures for Kids — Our Moon Mission

Drug discovery for SPG52 using olfactory stem cells

CIA: Mackay-Sim · co-CI: Cristino · co-CI: Avery
AU$ 330,000
2022
GURIIS — Griffith University Research Infrastructure Investment Scheme

GRIDD Tissue Culture Facilities

CIA: Cristino
AU$ 200,000
2019 – 2023
Schizophrenia Research Donation

Systems-based platform for biomarker discovery and drug screening

CIA: Cristino
AU$ 900,000
2016 – 2019
Australian Research Council Discovery Grant

Control of selective microRNA release via exosome vesicles

CIA: Hill · CIB: Cristino
AU$ 374,500
2020 – 2021
Centre for Children's Immunotherapy Research Grant

A novel off-the-shelf cellular immunotherapy for children with CD19+ blood cancers

CIA: Gandhi · CIB: Moore · CIC: Cristino · CID: Radford · CIE: Guillerey
AU$ 400,000
2020
GURIP — Griffith University Research Infrastructure Program

Automated imaging and analysis instrument for disease biology and drug discovery

CIA: Cristino · CIB: Mackay-Sim
AU$ 400,000
2020
MND Australia Innovator Grant

Boosting microglia phagocytosis as a therapeutic approach to treat MND

PI: White · Co-PI: Cristino · Co-PI: Ekberg · Co-PI: LaBella
AU$ 99,000
2020
GRIDD Collaborative Industry Grant

Stem-cell based diagnosis of schizophrenia disease

CIA: Cristino
AU$ 10,000
2019 – 2020
MHIQ Capacity Grant

Laying the foundation for highly integrative basic and responsive research in child health and disability

CIA: Kendall · CIB: Trembath · CIC: Baque · CID: Cristino
AU$ 250,000
2017 – 2019
Dementia Research Donation

Dementia biomarker identification

CIA: Cristino
AU$ 50,000
2017
Princess Alexandra Research Foundation

A novel immunotherapy strategy for lymphoma using artificial microRNA gene targeting

CIA: Bird · CIB: Gandhi · CIC: Cristino
AU$ 75,000
2016
Translational Research Institute Spore Grant

microRNA replacement therapy for indolent and aggressive prostate cancer

CIA: Batra · CIB: Russell · CIC: Cristino
AU$ 70,000
2015
Princess Alexandra Research Foundation

Marshalling Natural Killer cells in the fight against blood cancers

CIA: Gandhi · CIB: Cristino
AU$ 75,000